Fig. 2: Dose–response for grade 4 decreases in absolute neutrophil count in Cycle 1. | British Journal of Cancer

Fig. 2: Dose–response for grade 4 decreases in absolute neutrophil count in Cycle 1.

From: Safety, tolerability, and pharmacokinetics of Aurora kinase B inhibitor AZD2811: a phase 1 dose-finding study in patients with advanced solid tumours

Fig. 2

Based on ANC laboratory data. Figure shows the percentage grade 4 ANC decreases per cohort in Cycle 1 (coloured dots) versus planned total Cycle 1 dose. A grade 4 ANC decrease was defined as an ANC < 500 cells/μL post-baseline. The size of the coloured dots represents the relative cohort size. The black dashed line and grey shaded area represent the best fit of the data and 95% confidence interval based on simple logistic regression, respectively. Patients without ANC observations in Cycle 1 were excluded. ANC absolute neutrophil count, G-CSF granulocyte colony-stimulating factor.

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