Fig. 3: Geometric mean (±geoSD) AZD2811 whole blood concentrations.

a For days 1 and 4 regimens and b for day 1 only regimens. In Cohorts 1–6, PK blood samples (4 mL per sample) for determination of AZD2811 blood concentrations were collected from all patients on Cycle 1 Day 1 pre-dose, and at 1, 2, 4, 6, 8, 24, and 48 h (±15 min for each time point) from the start of infusion, then on Cycle 1 Day 4 pre-dose, and at 1, 2, 4, 6, 8, and 24 h (day 5), 48 h (day 6), 96 h (day 8) from the start of infusion, and in the morning on days 15, 16, and 22. A Cycle 2 Day 1 pre-dose sample and a 2-h sample (end of infusion) were also obtained. In Cohorts 7–12, PK blood samples were collected from all patients on Cycle 1 Day 1 pre-dose, and at 1, 2, 4, 6, and 8 h from the start of infusion, and in the morning on Days 4, 8, 12, and 22. G-CSF granulocyte colony stimulating factor, PK pharmacokinetics, Q3W every 3 weeks, Q4W every 4 weeks.