Fig. 5: Sequential therapy can decrease weight loss in vivo with comparable haematologic toxicity as a concurrent combination. | British Journal of Cancer

Fig. 5: Sequential therapy can decrease weight loss in vivo with comparable haematologic toxicity as a concurrent combination.

From: Sequential targeting of PARP with carboplatin inhibits primary tumour growth and distant metastasis in triple-negative breast cancer

Fig. 5

The impact of different treatment strategies was evaluated in three orthotopic xenograft models including MX1 (top row), HCC1806 (middle row) and MDAMB231 (bottom row). Kinetics of percent change in weight is shown in (a–c). Percent change in mice weight was calculated by normalising the weight on a given day by pre-treatment weight. x axis represents days post treatment until necropsy, and y axis represents percent change in weight. Impact of different treatments on white blood cell count (WBC) are shown in (d–f); neutrophil count shown in (g–i), and haemoglobin levels shown in (j–l). Sample sizes for each treatment are annotated at the top of each bar. Data are represented as mean +/– SEM. ANOVA with post test for multiple comparisons was performed. ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05.

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