Fig. 2: Optimisation of the cellular dissociation grading (CDG) system. | British Journal of Cancer

Fig. 2: Optimisation of the cellular dissociation grading (CDG) system.

From: Tumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer

Fig. 2

Two four-tiered grading systems were investigated, both based on tumour classification as CDG1, CDG2 and CDG3 and an additional split of the CDG2 class. a, b The set of CDG2 tumours was split based on the number of budding foci. Hazard ratios compared to CDG1 tumours increased and reached 1.5, 2.1, and 2.5 for CDG2/weak TB, CDG2/moderate TB and CDG3 tumours. c, d The set of CDG2 tumours was split based on the presence or absence of single-cell invasion (SCI). Counterintuitively, CDG2 tumours without SCI showed a (non-significant) trend to unfavourable prognosis compared to CDG2 tumours with SCI. e Relation between the number of budding foci, the classification of TB, and the CDG systems.

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