Fig. 3: Targeting intrinsic dependency on ser/gly synthesis in combination with RT has synergistic effects in cell growth in NSCLC cell lines.
From: Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer
a Growth curves of NSCLC cell lines treated with 10 µM sertraline and in combination with irradiation, 6 Gy. Calu-6 cell line was treated with 5 µM sertraline and 6 Gy irradiation. Data are presented as mean ± SD of 6 replicate wells and are representative of n ≥ 3 independent experiments. b Fold change of area under the curve (AUC) of cell growth curves of n ≥ 3 independent experiments. Data are represented as mean ± standard deviation. Individual dots represent independent observations. One-way ANOVA with Tukey’s multiple comparison test was used. Statistical analysis *p-value < 0.05, **p-value < 0.01, ***p-value < 0.001, ****p-value < 0.0001.
