Fig. 1: Microscopic illustration of a case with basaloid appearance and strong diffuse p16 expression.

a Overview over a OPSCC in low magnification; upper image: H&E, lower image: p16 immunohistochemistry; scalebar in both images: 200 µm. b High magnification view of selected areas with tumor buds highlighted by arrows. (upper image: H&E, lower image: p16 immunohistochemistry; scalebar in bith images: 20 µm). OPSCC: oropharyngeal squamous cell carcinoma; H&E: Hematoxylin-Eosin stain.