Fig. 5: ANRIL affected the cellular function of colorectal cancer cells and the regulation of cancer cells on HLECs via VEGF-C secretion. | Cancer Gene Therapy

Fig. 5: ANRIL affected the cellular function of colorectal cancer cells and the regulation of cancer cells on HLECs via VEGF-C secretion.

From: ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis

Fig. 5

A The ANRIL expression, colony formation, migration and invasion abilities of cancer cells with ANRIL knockdown (HCT-116/siANRIL, compare with HCT-116/NC) or overexpression (HCT-8/ANRIL, compared with HCT-8/Vector). B–D The VEGF-C expression at mRNA level (B), at protein level in cancer cells (C) and in the supernatant (D) of HCT-116 cells with ANRIL knockdown (HCT-116/siANRIL, compared with HCT-116/NC). E–G The VEGF-C expression at mRNA level (E), at protein level in cancer cells (F) and in the supernatant (G) of HCT-8 cells with ANRIL overexpression (HCT-8/ANRIL, compare with HCT-8/Vector). H The migration, invasion and tube formation abilities of cancer cells with ANRIL knockdown (HCT-116/siANRIL, compare with HCT-116/NC) or overexpression (HCT-8/ANRIL, compare with HCT-8/Vector). Data represent the mean ± SD of experiments conducted in triplicate experiments, *P < 0.05; **, ***, ****P < 0.01.

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