Fig. 4
From: Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress
Scotopic retinal function of rodΔVhl, rodΔVhl;Hif1a, rodΔVhl;Hif2a, and rodΔVhl;Hif1a;Hif2a mice at 6 months of age. a Scotopic ERG traces were recorded after light stimuli of increasing light intensities. Shown are representative traces. Cre-negative Vhlflox/flox mice served as controls. b Scotopic a-wave and b-wave amplitudes plotted as a function of stimulus intensity. Control mice were Cre-negative littermates of the respective strains. Shown are averages ± SD. N = 6 eyes (3 mice), except for controls of rodΔVhl;Hif2a (N = 5) and of rodΔVhl;Hif2a (N = 7), and for rodΔVhl;Hif1a;Hif2a (N = 4). *P < 0.05. Two-way ANOVA with Sidak’s multiple comparison test
