Fig. 7
From: Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas
Brf1 is essential during pancreas development. a Schematic showing the crosses performed to obtain the respective cohorts to assess the effects of Brf1 deletion in a mouse model of PDAC. b Kaplan–Meier curves showing pancreatic tumor-free survival in KPC Brf1+/+ (n = 32) vs KPC Brf1fl/ + (n = 26) mice (left panel) and for KPC Brf1fl/+ (n = 26) vs KPC Brf1fl/fl (n = 8) mice (right panel). Median survival for each genotype is indicated. c Kaplan–Meier survival curves showing pancreatic tumor-free survival in KC (Pdx1-Cre KrasG12D/+, continuous line, n = 44) vs KC HPRTLSL-BRF1 mice (Pdx1-Cre KrasG12D/+ HPRTLSL-BRF1, disrupted line, n = 33). d tRNAiMET and tRNAILE14 expression in pancreata from KC (Pdx1-Cre KrasG12D/+) and KC LSLBRF1 mice (Pdx1-Cre KrasG12D/+ HPRTLSL-BRF1) mice at 6 weeks post induction. N = 3 per genotype. e Staining for BRF1 in pancreata from KC (Pdx1-Cre KrasG12D/+) and KC HPRTLSLBRF1 mice (Pdx1-Cre KrasG12D/+ HPRTLSL-BRF1) mice at 6 weeks post induction
