Fig. 6
From: Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism
Working model of ATM regulates ferroptosis. Cystine deprivation or erastin treatment reduces intracellular cystine, cysteine, and GSH (reduced glutathione) level while increases ROS (reactive oxygen species) and oxidized glutathione (GSSG). These changes make the cells susceptible to iron-mediated cell death, ferroptosis. ATM-inactivation increases the nuclear translocation of MTF1 protein, which induces the expression of ferritin (FTH1 and FTL) and ferroportin (FPN1) to sustain low-labile iron condition and confer resistance to ferroptosis
