Fig. 2: Effects of ARRB1 or ARRB2 depletion on neuron death and neuroinflammation in PD models.
From: Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3
a–h Immunohistochemistry (a, c, e and g) and stereological counts (b, d, f and h) of TH+ DA neuron (a–d) and Iba-1+ microglia (e–h) in the SNc of LPS-induced PD models (n = 5). Scale bars, 200 µm (upper panels) or 40 µm (lower panels) in a, c, e and g. i mRNA levels of pro- and anti-inflammatory markers in the midbrain of PD mice (n = 3). j–q Immunohistochemistry (j, l, n, and p) and stereological counts (k, m, o, and q) of TH+ DA neuron (j–m) and Iba-1+ microglia (n–q) in the SNc of MPTP-induced PD models after AAV injection (n = 5). Scale bars, 200 µm (upper panels) or 40 µm (lower panels) in j, l, n and p. r mRNA levels of pro- and anti-inflammatory markers in the midbrain of PD mice after AAV injection (n = 3). Quantitative data are mean ± s.e. *P < 0.05, **P < 0.01, and ***P < 0.001.
