Fig. 7: Effects of ARRB1 and ARRB2 on Nprl3 expression in microglia.
From: Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3
a Normalized expression of pro-inflammatory markers measured by RNA-seq in microglia from WT and Arrb2−/− mice with or without LPS plus IFN-γ treatment for 6 h. b Heatmap of inflammatory genes in microglia from WT and Arrb2−/− mice. The genes shown are differentially expressed (padj ≤ 0.05, log2-fold change ≥1 or ≤ −1) in WT and Arrb2−/− mice. c Expression of 15 genes shown in b were measured by RT-PCR. d Gene expression in ARRB1 knockout microglia. Quantitative data are mean ± s.e. (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001.
