Fig. 1: High TRAF2 expression is associated with poor prognosis of HCC patients.
From: The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway
A The expression of TRAF2 mRNA level in HL7702 liver cell and HCC cell lines was determined by qPCR. Levels of significance: *p < 0.05, **p < 0.01, ***p < 0.001, (Student’s t-test). B TRAF2 protein levels in eight paired HCC clinical samples were detected by western blot. T: tumor tissue, A: adjacent non-tumor tissue. C, D HCC tissue microarrays containing 171 tumor tissues and corresponding tumor-adjacent normal tissues were stained for TRAF2 expression. IHC score was calculated via multiplying the percentage score by the intensity score [52, 53]. (***p < 0.001, Student’s t-test, two-tailed, mean ± SEM). E Representative images from immunohistochemical staining of TRAF2, Scale bar = 20 μm. F The correlation between TRAF2 expression and overall survival in HCC patients (p = 0.0002, Kaplan-Meier survival analysis). G The correlation between TRAF2 and p62 expression and overall survival of HCC patients (p < 0.0001, Kaplan-Meier survival analysis).
