Fig. 7: Depletion of Pinch impairs the effects of BMSCs in treatment of DSS-induced experimental colitis in mice. | Cell Death & Differentiation

Fig. 7: Depletion of Pinch impairs the effects of BMSCs in treatment of DSS-induced experimental colitis in mice.

From: The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway

Fig. 7

A Macroscopic appearances of colons in each group mice. B The quantification of colon length (n = 6). C Loss of basal body weight from day 0 to day 7 (%) after DSS induction (n = 6). D Mean DAI evaluations from day 0 to day 7 in each group (n = 6). E, F H&E staining of colonic sections (scale bar = 100 μm) followed by quantification. G Survival curve of DSS-induced acute inflammatory bowel disease. Mice were administrated with BMSC or BMSCdKO or corresponding vehicle (normal saline) followed by freely drinking water containing DSS (4%) or normal drinking water for 7 days (n = 12). Data are mean ± SD of 3 independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001.

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