Fig. 6: NTZ inhibits glioma growth in vivo. | Cell Death & Disease

Fig. 6: NTZ inhibits glioma growth in vivo.

From: Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma

Fig. 6

a Dissected tumors from a xenograft model with or without 27-day NTZ treatment after implantation. b Body weight changes of mouse models. c Tumor weight of two groups after the 27-day treatment. d Tumor volume changes of the two groups treated as described above. e HE and immunohistochemistry of ING, LC3, and SQSTM1 in vivo. Scale bar represents 50 or 100 μM. f The intracranial tumor size in orthotopic xenograft model. Scale bar represents 2000 μM. g The survival time of nude mice bearing glioma. h Representative LC–MS/MS chromatograms from TZO analysis of the brain homogenate samples. The statistic bars represent SD (*P < 0.05)

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