Fig. 4: ASC mediates propofol-induced pyroptosis. | Cell Death & Disease

Fig. 4: ASC mediates propofol-induced pyroptosis.

From: Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

Fig. 4

a Processing of caspase-1 in RAW264.7 and RAW-asc cell lines treated with LPS plus nigericin. The cells were primed with LPS for 4 h and then treated with nigericin for 2 h. b Exposure of RAW-asc cells to 300 μM propofol for 20, 30, 60 and 180 min induced pyroptosis through caspase-1 cleavage of GSDMD. Pyroptotic caspases were not activated in RAW264.7 cells. The results are representative of three independent experiments. Cell ext = cell extract; CASP1 = caspase-1

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