Fig. 2: SLAMF3^high T cells possess strong capability to produce inflammatory cytokines.

PBMCs (n = 17) of T2D patients were analyzed for inflammatory cytokine production by flow cytometry after 4-h stimulation by leukocyte activation cocktail. a Representative flow cytometric profiles about production of IL-17 by CD3⁺, CD3⁺CD8⁻, and CD3⁺CD8⁺ T cells were shown. b Representative flow cytometric profiles of SLAMF3 histogram in IL-17⁻ or IL-17⁺ in CD3⁺ (left), CD3⁺CD8⁻ (middle), and CD3⁺CD8⁺ T cells (right) were shown. c Summarized data about SLAMF3 MFI analyzed in IL-17 or IL-17⁻⁺ in CD3⁺ (left), CD3⁺CD8⁻ (middle), and CD3⁺CD8⁺ T cells (right) were shown. d Representative flow cytometric profiles about production of IFN-γ by CD3⁺, CD3⁺CD8⁻, and CD3⁺CD8⁺ T cells were shown. e Representative flow cytometric histogram profiles of SLAMF3 analyzed in IFN-γ^- or IFN-γ⁺ in CD3⁺, CD3⁺CD8⁻, and CD3⁺CD8⁺ T cells were shown. f Summarized data about SLAMF3 MFI analyzed in IFN-γ⁻ or IFN-γ⁺ in CD3⁺, CD3⁺CD8⁻, and CD3⁺CD8⁺ T cells were shown. ns no significant difference; *p < 0.05; **p < 0.01; ***p < 0.001