Fig. 4: Injection of CPC-EX in CVB3-induced myocarditis rats attenuated cardiomyocyte apoptosis and reduce CVB3 replication by regulating the Akt/mTOR pathway. | Cell Death & Disease

Fig. 4: Injection of CPC-EX in CVB3-induced myocarditis rats attenuated cardiomyocyte apoptosis and reduce CVB3 replication by regulating the Akt/mTOR pathway.

From: Exosomes derived from cardiac progenitor cells attenuate CVB3-induced apoptosis via abrogating the proliferation of CVB3 and modulating the mTOR signaling pathways

Fig. 4

a Representative bioluminescent pictures of myocarditis rats undergone tail vein injection with CPC-EX.The signal intensity of DIR-labeled CPCs-Ex in rats represented the amount of CPCs-Ex. b HE staining slides of hearts dissected from myocarditis rats from different groups shown that cardiomyocytes were swollen, deformed, and disordered in CVB3 groups. Scale bar: 400 and 100 μm. c TEM observation of cardiomyocytes shown nuclear fragmentation, nuclear shrinkage, and other cytopathic effects in the CVB3 group. Scale bar: 5 and 1 μm. d TUNEL analysis of hearts tissues from different groups (mean ± SEM, n = 3, one-way ANOVA). Scale bar: 100 μm. e, f Immunofluorescence and western blot analysis of VP1 of hearts tissues from different groups (mean ± SEM, n = 3, one-way ANOVA). Scale bar: 50 μm. *P < 0.05 and **P < 0.01 vs. Control

Back to article page