Fig. 5: PGK1 is a direct target gene of NFAT5. | Cell Death & Disease

Fig. 5: PGK1 is a direct target gene of NFAT5.

From: Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1

Fig. 5

a Venn diagram showing the intersection of five gene sets. b The relevance of NFAT5 with PGK1 and MET is displayed in the Renji cohort and TCGA database. c, d Relative PGK1 and MET mRNA expression in the control and NFAT5 knockdown PDAC cell lines. e Heatmap showing the counted numbers of four levels of PGK1 expression and its correlation with NFAT5. f Standard immunohistochemical scoring pictures of PGK1 expression in 311 pancreatic cancer tumors and adjacent normal tissues. g Respective IHC staining of NFAT5 and PGK1 in orthotopic xenograft models. h Respective IHC staining of NFAT5 and PGK1 in KPC mice. Assays shown in Fig. 5c, d were performed in hypoxia condition. *P < 0.05, **P < 0.01, ****P < 0.0001.

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