Fig. 6: PGK1 is a direct target gene of NFAT5. | Cell Death & Disease

Fig. 6: PGK1 is a direct target gene of NFAT5.

From: Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1

Fig. 6

a The sequence logo graph manifested the canonical binding site of NFAT5 predicted by JASPAR. b Four potential binding sequences were found in the PGK1 promoter region. c Mutated binding sites of NFAT5 lead to impaired luciferase activity in two cell lines. *P < 0.05, **P < 0.01, ****P < 0.0001.

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