Fig. 1: Upregulation of DLGAP1-AS1 was correlated with tumorigenesis of HCC. | Cell Death & Disease

Fig. 1: Upregulation of DLGAP1-AS1 was correlated with tumorigenesis of HCC.

From: Long non-coding RNA DLGAP1-AS1 facilitates tumorigenesis and epithelial–mesenchymal transition in hepatocellular carcinoma via the feedback loop of miR-26a/b-5p/IL-6/JAK2/STAT3 and Wnt/β-catenin pathway

Fig. 1

a DLGAP1-AS1 expression in normal human tissues (n = 570) were displayed by UCSC Genome Browser. b DLGAP1-AS1 expression levels in LIHC (red; n = 369) and normal (gray; n = 160) datasets obtained from GEPIA boxplot analysis. c DLGAP1-AS1 expression levels were assessed using qRT-PCR in four HCC cell lines and normal human liver epithelial cells THLE-3. d DLGAP1-AS1 knockdown and overexpression efficiencies were evaluated using qRT-PCR. e, f CCK-8 assay and TUNEL assay assessed the influence of DLGAP1-AS1 knockdown or overexpression on proliferation or apoptosis of Hep G2 and SNU-387 cells. Scale bar = 200 μm. g Wound healing assay was performed to determine the effect of DLGAP1-AS1 on HCC cell migration. Scale bar = 200 μm. h, i EMT-related factors in Hep G2 or SNU-387 cells after DLGAP1-AS1 knockdown or overexpression were respectively detected using qRT-PCR and WB. All data are presented as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01.

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