Fig. 5: Zmat3 loss does not overcome mutant KrasG12D induced cell senescence. | Cell Death & Disease

Fig. 5: Zmat3 loss does not overcome mutant KrasG12D induced cell senescence.

From: Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis

Fig. 5

a Growth analysis of primary cell lines derived from the lung epithelium of KPnull (n = 8) and KZ (n = 12) mice 10 weeks following i.n. Ad5-CMV-Cre infection. Mean ± SEM. b Accumulative cell number following 8 passages of primary KPnull (n = 8) and KZ (n = 12) cell lines. Mean ± SD, ***p < 0.0001. c Representative light microscope images of KrasG12D/p53−/− (KPnull) and KrasG12D/Zmat3−/− (KZ) cell lines 8 passages following their derivation. Scale, 10 μm. d Schematic representation of p53 target genes and their role in tumor suppression.

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