Fig. 5: Cordycepin and cDDP inhibit the migration and invasion ability of K180 and HK cells. | Cell Death & Disease

Fig. 5: Cordycepin and cDDP inhibit the migration and invasion ability of K180 and HK cells.

From: Cordycepin enhances the chemosensitivity of esophageal cancer cells to cisplatin by inducing the activation of AMPK and suppressing the AKT signaling pathway

Fig. 5

Representative images of wound healing (A, C) and perforation determination (A, C) after 48 h of treatment with either cordycepin (50 μM) or cDDP (2 μM) alone, or cDDP (1 μM) and cordycepin (25 μM) combined. The histogram describes the average migration distance (B, D) and the number of invasive cells (B, D), respectively. In addition, the expression of EMT-related proteins was detected (E). All data are shown as the (mean ± SD) of three independent experiments. **p < 0.01 or ***p < 0.001 relative to the control group (magnification ×100; scale bar 100 μm). DDP cisplatin, Cor cordycepin. [color numbers can be viewed on wileyonlinelibrary.com].

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