Fig. 2: LINC00998 impairs glioma proliferation in vitro and in vivo.
From: LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis
a, b Overexpression of LINC00998 inhibited A172 and U251 growth. c Knockdown of LINC00998 promoted U373 growth. d Overexpression of LINC00998 inhibited A172 and U251 clone formation ability. e knockdown of LINC00998 promoted U373 clone formation ability. f Overexpression of LINC00998 inhibited A172 and U251 sphere formation ability. g Knockdown of LINC00998 promoted U373 sphere formation ability. h Overexpression of LINC00998 blocked the cell cycle transition at G1/S. i Overexpression of LINC00998 decreased CDK1 expression and increased P27 protein expression. j H&E staining of brain sections demonstrated a significant decrease or increase in tumor volume after LINC00998 overexpression in U251 cells or knockdown in U373 cells, respectively, at 25 days post implantation (black arrows indicate tumor ___location). k, l Kaplan–Meier survival curves show a significant increase in median survival of U251 LINC00998OE tumor-bearing mice and decrease in median survival of both U373 sh#1 and sh#2 tumor-bearing mice. Scale bar = 500 μm (*P < 0.05, **P < 0.01, ***P < 0.001).
