Fig. 6: Elevation of ROR2 suppressed migration of PCa cells via inhibition of AKT2. | Cell Death & Disease

Fig. 6: Elevation of ROR2 suppressed migration of PCa cells via inhibition of AKT2.

From: ROR2 suppresses metastasis of prostate cancer via regulation of miR-199a-5p–PIAS3–AKT2 signaling axis

Fig. 6

(a) PC-3 cells with or without ROR2 overexpression were transfected with plasmid to overexpress either AKT1, AKT2, or AKT3. Cells were cultured for 72 h and the proteins levels of ROR2, AKT1, AKT2, and AKT3 in these PC-3 PCa cells were determined by the western blotting assay to confirm the overexpression of proteins. The β-actin was used as loading control. (b) Migration of PC-3 cells with or without ROR2, AKT1, AKT2, and AKT3 overexpression in (a) was determined by the transwell assay. (c) Proliferation of PC-3 cells with or without ROR2 or AKT2 overexpression in (b) was determined by the proliferation assay.

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