Fig. 7: ROR2 protein expression level is downregulated in metastatic prostate tumors. | Cell Death & Disease

Fig. 7: ROR2 protein expression level is downregulated in metastatic prostate tumors.

From: ROR2 suppresses metastasis of prostate cancer via regulation of miR-199a-5p–PIAS3–AKT2 signaling axis

Fig. 7

(a) ROR2 protein level in prostate tumors was determined by IHC staining with tissue array. The IHC staining intensity of ROR2 expression was scored as 3+ (strong), 2+ (moderate) to 1+ (weak), and 0 (no expression). (b) The intensities of ROR2 signaling in normal (N = 7) prostate tissues, low Gleason score PCa tissues (≦7, N = 17), and high Gleason score PCa tissues (>7, N = 23) were separated into weak, moderate, and strong ROR2 IHC staining. (c) A summary of signaling pathway regulated by ROR2 in PCa. Red arrows indicated signaling proteins being enhanced by elevation of ROR2, while blue arrows indicated signaling proteins being suppressed by the elevation of ROR2. Scale bar represented 50 μm.

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