Fig. 1: The expression of MDA5 and anti-CMV IgM is higher in some progressive vitiligo patients. | Cell Death & Disease

Fig. 1: The expression of MDA5 and anti-CMV IgM is higher in some progressive vitiligo patients.

From: Intracellular virus sensor MDA5 exacerbates vitiligo by inducing the secretion of chemokines in keratinocytes under virus invasion

Fig. 1

a The anti-CMV IgM levels in 56 vitiligo patients and 26 healthy controls. The patients with the positive anti-CMV IgM were indicated in red. b The VASI scores of vitiligo patients with positive anti-CMV IgM or negative anti-CMV IgM. n = 5. c The Western-blot of MDA5 in the epidermis of perilesional skin of vitiligo patients with positive or negative anti-CMV IgM, in the apparently healthy epidermis of vitiligo patients with positive anti-CMV IgM and in the epidermis of healthy controls. n = 3. d, e The expression of MDA5 (d) and IFN-β (e) in epidermis of perilesional skin of vitiligo patients with positive or negative anti-CMV IgM, in the apparently healthy epidermis of vitiligo patients with positive anti-CMV IgM and in the epidermis of healthy controls, by immunofluorescence assay. n = 5, Bar = 50 μm. The data are presented as the mean ± SD across three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001. ns, not significant.

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