Fig. 6: Oxidized ATM-mediated EMR promotes tumor formation of CSCs in mice xenografts. | Cell Death & Disease

Fig. 6: Oxidized ATM-mediated EMR promotes tumor formation of CSCs in mice xenografts.

From: Oxidized ATM promotes breast cancer stem cell enrichment through energy metabolism reprogram-mediated acetyl-CoA accumulation

Fig. 6

a Photos of the xenograft tumors dissected from the nude mice at the seventh week after being subcutaneously injected with BT549 mammosphere cells. When tumor volume reaches around 50 mm3, mice were randomized into five groups and administered with KU60019 (50 mg/kg, three times a week), or UK5099 (10 μg/kg, once every 2 days), acetate (150 mg/kg, three times a week), and acetate (250 mg/kg, three times a week) alone or in combination, via intraperitoneal (i.p.) injection. b Tumor growth curve (*P < 0.05, **P < 0.01). c The average tumor weight of each group. d Acetyl-CoA productions of xenograft tumors. e GLUT1, PKM2, PDHa, H4ac, and SOX2 levels were determined in tumor tissues by IHC analyses.

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