Fig. 5: Circ_0057558 was elevated in NAFLD and knockdown circ_0057558 inhibited lipogenesis. | Cell Death & Disease

Fig. 5: Circ_0057558 was elevated in NAFLD and knockdown circ_0057558 inhibited lipogenesis.

From: Circ_0057558 promotes nonalcoholic fatty liver disease by regulating ROCK1/AMPK signaling through targeting miR-206

Fig. 5

A The feature of circ_0057558 and Sanger sequencing result. B Relative expression levels of circ_0057558 and SLC39A10 at the indicated time after antinomycin D treatment. C Relative expression levels of circ_0057558 and SLC39A10 after RNase R treatment. D FISH analysis of subcellular localization of circ_0057558. E circ_0057558 level in HFD-fed mice and control mice. F circ_0057558 level in cells treated with FFA or control. G Representative oil-red o staining images of cells transfected with sh-circ_0057558 or sh-NC following FFA or control treatment. H Secreted TG level in cells with the transfection of sh-circ_0057558 or sh-NC following FFA or control treatment. I Protein levels of lipogenesis-related proteins in cells transfected with sh-circ_0057558 or sh-NC following FFA or control treatment. J Quantifications of I. *p < 0.05, **p < 0.01, and ***p < 0.001.

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