Fig. 2: Enhanced SAP130 and Mincle expression in patients with acute tubule necrosis. | Cell Death & Disease

Fig. 2: Enhanced SAP130 and Mincle expression in patients with acute tubule necrosis.

From: SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury

Fig. 2

A–C Patients with acute tubular necrosis (ATN, n = 9) and patients with glomerular minor lesion as controls (Ctrl, n = 8) were enrolled. Renal pathology and semiquantitative analysis showed significant tubule injury in ATN patients compared to controls. Scale bar, 100 μm. Macrophages were detected by CD68 immunostaining. Scale bar, 50 μm. D Enhanced SAP130 and Mincle expression were detected in ATN patients by immunofluorescence staining. Scale bar, 50 μm. E–F SAP130 and Mincle positive cells were quantified. Data were presented as mean ± SD. **p < 0.01, ***p < 0.001, and ****p < 0.0001 compared to Ctrl. Ctrl Control, Hum ATN human acute tubular necrosis.

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