Fig. 6: MiR-219c-3p overexpression ameliorated acute kidney inflammation. | Cell Death & Disease

Fig. 6: MiR-219c-3p overexpression ameliorated acute kidney inflammation.

From: SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury

Fig. 6

A Schematic overview of study in AKI model induced by UUO mice with miR-219c-3p overexpression via lentiviral vector transfection. B Expression of miR-219c-3p in the UUO kidney transfected with miR-219c lentiviral or NC as control. C–D Representative sections of mice kidney stained for F4/80+ macrophages. The number of infiltrated macrophages were quantified. Scale bar, 100 μm. E–G Mincle, MCP-1, TNF-α was detected by RT-PCR in the kidney which were inhibited by miR-219c-3p overexpression. Data were presented as mean ± SD. *p < 0.05 compared to NC_UUO. NC_UUO, UUO mice treated with empty lentiviral vector as a negative control. MiR-219c lentiviral_UUO, UUO mice treated with miR-219c-3p overexpression via lentiviral transfection.

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