Fig. 4: Effect of genetic inhibition of RIPK3 and MLKL on acute cell death and subacute lesion volume after CCI. | Cell Death & Disease

Fig. 4: Effect of genetic inhibition of RIPK3 and MLKL on acute cell death and subacute lesion volume after CCI.

From: Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis

Fig. 4

A Representative image and B quantification of PI + cell counts at 6 h after CCI were not different between RIPK3−/− and WT mice in all brain regions examined. (n = 6–8/group, p = ns, Scale bar = 100 μm). C Representative image and D quantification of Fluoro Jade B + cell counts at 6 h after CCI were not different between RIPK3−/− and WT mice in all brain regions examined (n = 6–8/group, p = ns, Scale bar = 100 μm). At 2 months after injury, lesion volume was similar between E, F WT and RIPK3−/− (n = 9–10/group), G, H WT and MLKL−/− (n = 14–16/group) mice.

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