Fig. 5: The possible mechanisms of ROS-regulated gene transcription depending on promoter G4s. | Cell Death & Disease

Fig. 5: The possible mechanisms of ROS-regulated gene transcription depending on promoter G4s.

From: Crosstalk between G-quadruplex and ROS

Fig. 5

Under oxidative stress, ROS can lead to OG formation in the G-rich region of promoters, which recruits OGG1 to clear OG and form the AP site. APE1 then binds to AP when looped out in the G4 fold to recruit TFs. On the other hand, ROS can also directly attack the G4 structure of the promoter region and form OG, which facilitates the recruitment of PARP1 and the binding of other transcriptional activating proteins to promote gene expression.

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