Fig. 6: Crosstalk between Nrf2, stress particles, and G4. | Cell Death & Disease

Fig. 6: Crosstalk between Nrf2, stress particles, and G4.

From: Crosstalk between G-quadruplex and ROS

Fig. 6

H2O2-induced ROS promotes Nrf2 protein translation via EF1a interaction with the G4 in Nrf2 5′UTR. Activating downstream antioxidant genes enhances antioxidant capacity and protects normal cells from oxidative damage. Stress-induced DNA damage promotes the formation of DNA-G4 and tiRNA-G4 complex, which trigger SGs assembly by recruiting cytosolic proteins, which involved in antioxidant response and mRNA translation.

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