Fig. 2: Analysis of the DC subsets infiltrating LLC tumor microenvironment under SULT2B1b perturbation. | Cell Death & Disease

Fig. 2: Analysis of the DC subsets infiltrating LLC tumor microenvironment under SULT2B1b perturbation.

From: Harnessing the reverse cholesterol transport pathway to favor differentiation of monocyte-derived APCs and antitumor responses

Fig. 2

A Mice challenged with LLC-Mock and LLC-SULT2B1b tumors were sacrificed 12 days after tumor challenge and evaluated for tumor weight. Mean and s.d. of 6 mice/group. ****P < 0.0001 (Student’s t-test). The same tumors were analyzed for the number of CD11c+CD103+ cDC1 (B) and monocyte-DCs/mg of tumors (C). Mean and s.d. of 6 mice/group. **P < 0.01; ns, not significant (Student’s t-test). D Mice challenged with LLC-Mock and LLC-SULT2B1b tumors were sacrificed 10 days after tumor challenge and evaluated for tumor weight. Mean and s.d. of 7 mice/group. ****P < 0.0001 (Student’s t-test). E-G Numbers of monocyte-DCs (E) CD26+CD64+MAR-1- cDC2 (F) and CD26+CD64+MAR-1+ Inf-cDC2/mg of tumors (G). Mean and s.d. of 6-7 mice/group. *P < 0.05 (Student’s t-test).

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