Scheme 1 | Cell Death & Disease

Scheme 1

From: Harnessing the reverse cholesterol transport pathway to favor differentiation of monocyte-derived APCs and antitumor responses

Scheme 1

Synthesis of 22(S)-Hydroxycholesterol-3-sulfate sodium salt (PFM037)a. aReagents and conditions: (a) isoamyl bromide, Mg, 0 °C to rt, 5 h; (b) i. Ac2O, 4-DMAP, CH2Cl2, pyridine, rt, 20 h; ii. pTsOH, dioxane/H2O, 80 °C, 1 h; (c) i. SO3-pyridine complex, pyridine, rt, 4 h; ii. 1.25 M NaOH in MeOH, reflux for 1 h, then rt overnight.

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