Fig. 6: TMP195 treatment greatly inhibited CRLM growth and vascularization. | Cell Death & Disease

Fig. 6: TMP195 treatment greatly inhibited CRLM growth and vascularization.

From: Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis

Fig. 6

A The treatment regimen with TMP195. B The weight changes of mice in vehicle and TMP195 groups during 0–14 dpi. C The liver and CRLM samples at 14 dpi with/out TMP195 treatment. D The liver weights with/out TMP195 treatment at 14 dpi. E IHC with anti-CD34 antibodies showed greatly disturbed neovascularization within CRLM in TMP195-treated liver biopsies; *the numbers in the lower left corner of the samples were in relation to the livers as shown (C). The treatment significantly decreased CD34+ microvascular density (MVD) and the number of CD34+-positive cells per HPF (F). MVDs were counted in the most active areas of neovascularization per 200× field according to the previous method. *p < 0.05; ***p < 0.001.

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