Table 2 Univariate and multivariate Cox regression analysis RNF157-AS1 for OS, PFS, or PPS of EOC patients in TCGA database.

From: Differential effects of the LncRNA RNF157-AS1 on epithelial ovarian cancer cells through suppression of DIRAS3- and ULK1-mediated autophagy

Variables

OS

PFS

PPS

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

Univariate analysis

Age (<60 vs. ≥60)

1.371

1.074–1.749

0.011*

1.132

0.888–1.444

0.317

1.321

1.033–1.689

0.027*

TNM stage (I/II vs. III/IV)

1.958

0.923–4.157

0.080

1.279

0.980–1.668

0.070

1.433

0.675–3.041

0.349

Grade (G1/G2 vs. G3/G4)

1.139

0.802–1.616

0.467

1.055

0.765–1.455

0.745

1.203

0.844–1.715

0.306

Site (unilateral vs. bilateral)

1.070

0.799–1.434

0.648

1.109

0.858–1.435

0.428

1.029

0.768–1.378

0.849

Neoplasm status (tumor free vs. with tumor)

7.912

4.501–13.907

<0.001*

5.578

3.816–8.152

<0.001*

3.882

2.212–6.815

<0.001*

Lymphatic invasion (no vs. yes)

1.162

0.717–1.882

0.543

1.122

0.750–1.679

0.575

0.909

0.558–1.482

0.703

RNF157-AS1 expression (low vs. high)

0.734

0.575–0.937

0.013*

0.926

0.727–1.180

0.533

0.769

0.601–0.983

0.036*

Multivariate analysis

Age(<60 vs. ≥60)

1.267

0.976–1.645

0.075

–

–

–

1.253

0.963–1.630

0.093

Neoplasm status (tumor-free vs. with tumor)

7.919

4.504–13.924

<0.001*

5.578

3.816–8.152

<0.001*

3.97

2.260–6.975

<0.001*

RNF157-AS1 expression (low vs. high)

0.72

0.554–0.935

0.014*

–

–

–

0.771

0.593–1.003

0.053

  1. The bold values indicated these data are statistically different, including HR, 95% CI and P value.
  2. *P < 0.05.
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