Fig. 8: Schematic diagram illustrating the function of USP22 on modulation of ZEB1-induced VEGFA transcription and the role of USP22 in promotion of HCC progression.
From: USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma
USP22 maintains ZEB1 stability by triggering deubiquitination of ZEB1. USP22/ZEB1 being recruited to the ZEB1 binding elements of VEGFA promoter region, inducing the ubiquitination of histone H2B, enhances the transcription of VEGFA.This effect ultimately leads to increased expression and secretion of VEGFA, which may accelerate HCC progression.
