Fig. 6: STOML2 repressed GEM chemoresistance in vivo. | Cell Death & Disease

Fig. 6: STOML2 repressed GEM chemoresistance in vivo.

From: STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation

Fig. 6

A Under GEM treatment, subcutaneous xenograft tumors with STOML2 overexpression had a lower growth rate than the control group. B Representative figures of tumors in nude mice (N = 7/group). C Subcutaneous xenograft tumors derived from PANC1-lenti-NC cells or PANC1-lenti-STOML2 OE cells. D Tumor weights of the subcutaneous xenograft tumors. E Immunoblot showing the protein levels of PARL and vinculin after STOML2 overexpression in subcutaneous xenograft tumors. F IHC confirmed STOML2 overexpression in PANC1-lenti-STOML2 OE cells compared to control cells. F–H Cell proliferation and cell death in vivo were also analysed by IHC using anti-Ki67 and cleaved caspase 3, respectively. Scale bar represents 50 μm G Graphical diagram of STOML2-inhibited mitophagy-induced chemoresistance in pancreatic cancer cells through the STOML2/PARL/PINK1 axis. OMM: outer mitochondrial membrane; IMM: inner mitochondrial membrane. *P < 0.05; **P < 0.01; ***P < 0.001.

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