Fig. 8: Comparison of miR-182 and IL-8 expression in bone-metastatic tumor specimens from NSCLC patients. | Cell Death & Disease

Fig. 8: Comparison of miR-182 and IL-8 expression in bone-metastatic tumor specimens from NSCLC patients.

From: A novel microRNA-182/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer

Fig. 8

A Quantification of the IL-8 level in primary NSCLC tumors (Primary tumor, n = 45), non-tumor lung tissues (Normal, n = 45), and bone metastatic tumors from NSCLC patients (Bone-met, n = 15) using qPCR. B Pearson’s correlation analysis of IL-8 and miR-182 levels in 15 bone-metastatic tumor specimens. C Comparison of the overall survival between the 1925 NSCLC patients with high or low levels of IL-8 by Kaplan–Meier analysis. Gene expression data and overall survival information were obtained from GEO, EGA and TCGA (CAARRAY, GSE14814, GSE19188, GSE29013, GSE30219, GSE31210, GSE3141, GSE31908, GSE37745, GSE43580, GSE4573, GSE50081, GSE8894, TCGA). D Schematic model showing that the miR-182/IL-8 regulatory axis plays an important role in regulating bone metastasis of lung cancer. The average values ± SEM of three separate experiments are plotted. **P < 0.01; ***P < 0.001.

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