Fig. 1: Overexpression of IL-34 accelerated AML progression. | Cell Death & Disease

Fig. 1: Overexpression of IL-34 accelerated AML progression.

From: Sox13 and M2-like leukemia-associated macrophages contribute to endogenous IL-34 caused accelerated progression of acute myeloid leukemia

Fig. 1

A Schematic overview showing the establishment of the MA9 and MA9-IL-34 mouse AML models. B–F 1 × 105 GFP+BFP+ cells were transplanted into recipient mice and the progression of AML was studied. B The PB leukemia cell levels were monitored at indicated time points (n = 4). C The survival of AML mice is shown in Kaplan-Meier curves (MA9, n = 10; MA9-IL-34, n = 11). D–E The size and weight of spleens (D) and livers (E) on day 17 are shown. F The HE-stained sections of BM, spleen, liver, kidney and skin were examined under a light microscope. Scale bars: 50μm. Data are presented as mean ± S.E.M. Unpaired Student’s t test and Kaplan–Meier estimates were used. **p < 0.01, ***p < 0.001.

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