Fig. 7: Proposed working model for EphB6/EphrinB2 gain of function in cortical soma spacing. | Cell Death & Disease

Fig. 7: Proposed working model for EphB6/EphrinB2 gain of function in cortical soma spacing.

From: Overexpression of EphB6 and EphrinB2 controls soma spacing of cortical neurons in a mutual inhibitory way

Fig. 7

Overexpression of EphB6 receptor or EphrinB2 results in soma clumping of cortical neurons, whereas simultaneous overexpression of both eliminates the clumping phenotype. The interaction of extracellular ___domain of EphB6 with EphrinB2, and EphB6 with intracellular ___domain of EphrinB2 are the key components that may restore intracellular signaling pathways that are responsible for soma spacing impaired by overexpression EphB6 or EphrinB2.

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