Fig. 2: The role of autophagy in cancer stem cells.
From: Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications
In summary, autophagy plays approximately five roles in cancer stem cells. Autophagy can affect NOTCH, NANOG, PI3K-AKT, SOX2 through LC3, BCL-1, Ambra1, ATG5, mTOR- β- Actin signaling pathways regulate the proliferation, renewal, differentiation, invasion, metastasis, survival, and drug resistance of cancer stem cells.
