Fig. 3: BI6727 attenuates kidney fibrosis in mice subjected to UUO.
From: Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis
A, B Representative images of HE and Masson staining, and immunohistochemistry detection of Collagen III, α-SMA, and F4/80 in sham and UUO mice treated with or without BI6727. Scale bar = 50 µm except scale bar (α-SMA) = 20 µm. C, D Western blot analysis of FN, α-SMA, and Collagen III in kidneys of all groups of mice. The GAPDH for FN and α-SMA in this blot were from same experiment, same samples and processed in parallel. E qRT-PCR analysis of FN, α-SMA, Collagen I, Collagen III, and Collagen IV in kidneys of all groups of mice. n = 6. *P < 0.05, **P < 0.01, ***P < 0.001.
