Fig. 3: Conditional deletion of Dlk2 exhibits high bone mass in OVX condition.
From: Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation
A Representative 3D micro-CT reconstruction images of distal femurs from 20-week-old Ctsk-Cre-;Dlk2fl/fl (WT) and Ctsk-Cre+;Dlk2fl/fl (CKO) female mice. Twelve-week-old WT and CKO female mice underwent ovariectomy (OVX) and were sacrificed after 2 months. B Quantitative micro-CT analysis of images shown in A; Conn.D connectivity density. C Representative images of H&E- and TRAP-stained sections from WT and CKO ovariectomized mice. The femurs were decalcified, embedded in paraffin and stained with H&E and TRAP. D Bone histomorphometric analysis of the TRAP-stained sections shown in C. (Scale bar, 100 μm, mean ± SD, Student’s tests, *p < 0.05, **p < 0.01, n = 6 for each genotype).
