Fig. 5: BRD4 arginine methylation promotes ovarian cancer metastasis.
From: Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion
a–c IB analysis of E-cadherin, N-cadherin, MMP2, MMP9 derived from HEK293T cells (a), A2780 cells (b) and shBRD4-A2780 cells (c) infected with BRD4-WT or BRD4-R3K. d and e IB analysis of E-cadherin, N-cadherin, MMP2, MMP9 derived from A2780 cells (d) and SKOV3 cells (e) transfected with shPRMT1-1 and shPRMT1-2. f–h Representative images and statistical analysis of migration and invasion of A2780-shBRD4 cells transfected with BRD4-WT or BRD4-R3K assessed by Transwell assays. *P < 0.05, **P < 0.01, ****P < 0.0001. i–k Representative images and statistical analysis of migration and invasion of A2780 cells transfected with shPRMT1-1 or shPRMT1-2 assessed by Transwell assays. **P < 0.01, ****P < 0.0001.
