Fig. 1: SIRT4 expression was down-regulated in SAP.
From: Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis
A The correlation between SIRT4 and AP was discovered by bioinformatics analysis. B SIRT4 mRNA expression was downregulated in AP patients (GEO dataset GSE194331). C SIRT4 is localized in mitochondria. D Animal SAP model and experimental protocol for drug (Fer-1, PX478) administration. E Serum amylase level and lipase activity. F Typical HE staining images of pancreatic tissue. Scale bar = 100 µm. G Protein expression level of SIRT4 in the pancreas. H Viability of AR42J cells. I The protein expression level of SIRT4 in AR42J cells. Sham group (saline), SAP group (4 g/kg L-Arg), NC group (PBS), L-Arg group (10 mg/ml L-Arg). E, G used GAPDH as the reference protein. *P < 0.05, ***P < 0.001. n = 6 per group.
