Fig. 7: Intervention in the c-Myc/FAM83F/Wnt/β-catenin axis inhibited CC progression in a mouse xenograft model. | Cell Death & Disease

Fig. 7: Intervention in the c-Myc/FAM83F/Wnt/β-catenin axis inhibited CC progression in a mouse xenograft model.

From: Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/β-catenin signaling activation

Fig. 7

A Morphology of tumor xenograft from each mouse (n = 6 for each group). B Tumor weight from each mouse at the end of the experiment. C Tumor volume from each mouse was measured and recorded every three days during the experiment. D The expression of c-Myc, FAM83F, β-catenin in the nucleus, and β-catenin in cytoplasm in tumor xenografts were assessed using western blotting. E Immunofluorescence was used to detect the protein levels of Wnt/β-catenin pathway-related factors (Cyclin D1, survivin, and CDK4), proapoptotic protein Bim, and enzymes involved in glycolysis (LDHA and PDK1). Scale bars, 200 μm and 100 μm. The data represent the mean ± SD of three independent experiments, and the level of significance was indicated by ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05. ns no significance (p > 0.05).

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