Fig. 6: CRABP2 affects the subcellular localization of HIF1α.
From: CRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α
A The expression of CRABP2 in ovarian cancer drug-resistant cells and parental cells detected by immunofluorescence. B and C, Effects of CRABP2 knockdown on HIF1α expression level and localization in ovarian cancer drug-resistant cells detected by immunofluorescence (B) and nuclear-cytoplasmic protein separation (C). D Effects of ATRA on HIF1α localization in CRABP2 overexpression cells. E, Effect of DDP combined with ATRA on the viability of HIF1α-knockdown resistant ovarian cancer cells. F Effect of YC-1 on DDP IC50 in drug-resistant ovarian cancer cells. G The effect of YC-1 combined with DDP on the death of drug-resistant ovarian cancer cells was detected by flow cytometry.
